|
rs977706
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.
|
30926877 |
2019 |
|
rs9607715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, IL17R rs9607715 and IL17F rs763780 polymorphisms are associated with the susceptibility and severity of HD, respectively.
|
30474404 |
2018 |
|
rs9606615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of the IL17R rs9606615 T allele was higher in patients with HD than in normal subjects (p = .011).
|
30474404 |
2018 |
|
rs917997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And in another SNP rs917997, AA+AG genotype presented an increased frequency in HT subjects compared with controls (P = 0.046, OR = 1.53).
|
26566691 |
2016 |
|
rs878854066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Pro72Arg (rs 1042522) SNP we found these rates in HT patients: 11.4% wild-type C/C (Pro72Pro), 24.0% heterozygous G/C (Pro72Arg), 64.6% homozygous G/G (Arg72Arg).
|
25935255 |
2015 |
|
rs867770797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined firstly the possible association of EDN1 (G5665Tand T-1370G) and EDNRA (C+70G and G-231A) single nucleotide polymorphisms (SNPs) with the occurrence of HT, and evaluates the relationship between genotypes and clinical/laboratory manifestation of HT.
|
24815860 |
2014 |
|
rs853326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the genomic region (11.5cM) containing the Tg gene by genotyping seven microsatellite markers and four SNPs located respectively at exon 10 (Ser715Ala), exon 12 (Met1009Val), exon 21 (Ala1483Ala) and exon 33 (Arg1980Trp) in 15 Tunisian multiplex families affected with AITD including Graves' disease (GD) and Hashimoto's thyroiditis (HT) (members: 87; patients: 27 GD and 16 HT).
|
18656705 |
2008 |
|
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, single-nucleotide polymorphisms (SNPs) of IL28B rs8099917 (IL28 G/T) and IL29 rs30461 (IL29 T/C) were studied in 99 patients with HT and 100 healthy controls.
|
27617784 |
2016 |
|
rs791903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10<sup>-6</sup>), rs75201096 inside GNA14 (P = 2.41 × 10<sup>-5</sup>) and rs791903 inside IP6K3 (P = 3.16 × 10<sup>-5</sup>).
|
30284222 |
2019 |
|
rs78645479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a promotor variant (rs78645479) in an index case of vitiligo + HT + candidiasis and evaluated its clinical and functional relevance.
|
26267147 |
2015 |
|
rs763780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, IL17R rs9607715 and IL17F rs763780 polymorphisms are associated with the susceptibility and severity of HD, respectively.
|
30474404 |
2018 |
|
rs763780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicated that the frequencies of IL-17F/rs763780 genotypes in patients with GD and HT differed significantly from their controls (P = 0.013 and P = 0.005, respectively); the G allele frequencies were also significantly higher in the patient groups than the control groups (P = 0.002 and 0.001, respectively).
|
22816799 |
2012 |
|
rs7629750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an obvious difference in the genotype distributions of rs12492609 and rs7629750 between HT patients with hypothyroidism and those without hypothyroidism (<i>p</i> = 0.034 and <i>p</i> = 0.023, respectively).
|
31553233 |
2019 |
|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>STAT4</i> rs7574865 polymorphism was significantly associated both with Graves' disease (GD) and Hashimoto's thyroiditis (HT) susceptibility.
|
30666271 |
2018 |
|
rs756763
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.
|
30926877 |
2019 |
|
rs7537605
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A genome-wide direct comparison between HT and GD revealed an SNP at the VAV3 locus with genome-wide significant association signals (rs7537605: P(combined) = 3.90 × 10(-8); odds ratio(combined) = 1.77; 95% confidence interval = 1.44-2.17).
|
25429627 |
2015 |
|
rs7537605
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
A genome-wide direct comparison between HT and GD revealed an SNP at the VAV3 locus with genome-wide significant association signals (rs7537605: P(combined) = 3.90 × 10(-8); odds ratio(combined) = 1.77; 95% confidence interval = 1.44-2.17).
|
25429627 |
2015 |
|
rs7530511
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
|
rs75201096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10<sup>-6</sup>), rs75201096 inside GNA14 (P = 2.41 × 10<sup>-5</sup>) and rs791903 inside IP6K3 (P = 3.16 × 10<sup>-5</sup>).
|
30284222 |
2019 |
|
rs744166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL-23R (rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products.
|
24460100 |
2014 |
|
rs744166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Allele A of STAT3 SNP rs744166 A>G was significantly more frequent in both HT and GD patients, while allele G was significantly more frequent in the control group.
|
26204395 |
2015 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For 139 Graves' disease (GD) patients, 116 Hashimoto's disease (HD) patients and 76 control subjects, we genotyped the following polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP): vitamin D receptor (VDR): rs731236, rs7975232, rs2228570 and rs1544410; group-specific component (GC): rs7041 and rs4588; and CYP2R1: rs10741657.
|
25046415 |
2014 |
|
rs72928038
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Seven newly identified loci for autoimmune thyroid disease.
|
22922229 |
2012 |
|
rs7178239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele C and genotype CC in rs7178239 of SELENOS showed different trend in GD and HT patients when compared with the control.
|
28499373 |
2017 |
|
rs7171171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three genetic variants showed nominal association with HT; rs10774625 in ATXN2 gene (p = 0.0149, OR = 0.73, CI = 0.56-0.94), rs7171171 near RASGRP1 gene (p = 0.0356, OR = 1.4, CI = 1.02-1.92) and rs11675434 in TPO gene (p = 0.041, OR = 1.31, CI = 1.01-1.69).
|
27268232 |
2016 |